如果您對(duì)該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: 1646321-63-2
產(chǎn)品型號(hào):
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
1646321-63-2，LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
1646321-63-2
的詳細(xì)介紹
1646321-63-2，LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
|
別名
|
化合物L(fēng)NP023 hydrochloride , Iptacopan HCl , LNP023 hydrochloride ,
|
|
純度
|
99.84%
|
|
分子量
|
458.98
|
|
分子式
|
C25H31ClN2O4
|
|
CAS No.
|
1646321-63-2
|
|
產(chǎn)品描述
|
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
|
|
體外活性
|
LNP023 demonstrates excellent selectivity over other proteases affording IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM)[3].
|
|
體內(nèi)活性
|
LNP023 (20-180 mg/kg; oral administration) is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats and prevents KRN (150 μL)-induced arthritis in mice[2]. After oral administration (rat 30 and, dog 10 mg/kg), LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM)[3].
|
SYNTHBIO 是致力于從事生命科學(xué)研究和提供高質(zhì)量的生物技術(shù)外包服務(wù)公司（CRO），主營(yíng)多肽及小分子等化合物定制合成，同時(shí)還擁有自己開(kāi)發(fā)的細(xì)胞株、菌株等產(chǎn)品，并承接相關(guān)的技術(shù)服務(wù)以及品牌（細(xì)胞、菌株、抗體、耗材、儀器）產(chǎn)品。
24小時(shí)保姆式服務(wù)售前售后13295518198（QQ/微信/電話）汪亞南
天地合氣，萬(wàn)物自生。
