氣道平滑肌是維持氣道張力的根本。它存在于氣管、支氣管樹直至終末支氣管。其特異的超微結(jié)構(gòu)特點(diǎn)和調(diào)節(jié)機(jī)制是實(shí)現(xiàn)氣管正常生理功能的基礎(chǔ)。有證據(jù)表明氣管平滑肌在肺的發(fā)育過程以及諸如**病、慢性支氣管炎和肺氣腫等疾病狀態(tài)下經(jīng)歷著顯著的表型變化。另外，氣道平滑肌通過分泌細(xì)胞因子和趨化因子等促炎介質(zhì)，發(fā)揮免疫調(diào)節(jié)功能。培養(yǎng)的氣管平滑肌細(xì)胞能表達(dá)三種P21活化的激酶（PAK）的同型異構(gòu)體和PAK1，并通過P38 mapk信號途徑參與氣管平滑肌細(xì)胞的遷移。氣道平滑肌細(xì)胞增殖已成為人們關(guān)注的焦點(diǎn)，因?yàn)樵?*病人中，此細(xì)胞是氣道壁重塑反應(yīng)中數(shù)量上的重要組分，并被認(rèn)為是新型抗**病藥物的作用目標(biāo)。
人氣管平滑肌細(xì)胞提取于人氣管組織，二代凍存。每管含有細(xì)胞數(shù)>5×105 cells/ml，此細(xì)胞通過對alpha-SMA和Desmin免疫熒光染色驗(yàn)證，經(jīng)測試不含有HIV-1、HBV、HCV、支原體、細(xì)菌、酵母和真菌。細(xì)胞可以達(dá)到15倍增。? ?
推薦培養(yǎng)基：平滑肌細(xì)胞培養(yǎng)基 (SMCM, Cat. #1101)
|
貨號
|
3410
|
|
產(chǎn)地
|
美國
|
|
縮寫
|
HTSMC
|
|
規(guī)格
|
5 x 10^5 /1ml
|
|
用途
|
科研
|
|
儲存
|
液氮
|
|
運(yùn)輸
|
干冰
|
|
關(guān)鍵字
|
人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC 人氣管平滑肌細(xì)胞 HTSMC
|
公司簡介
|
合肥星肽生物科技有限公司作為專業(yè)的ScienCell中國代理商，專業(yè)經(jīng)營實(shí)驗(yàn)室科研用原代細(xì)胞、原代細(xì)胞專用培養(yǎng)基、原代細(xì)胞無血清培養(yǎng)基、干細(xì)胞、干細(xì)胞培養(yǎng)基、干細(xì)胞無血清培養(yǎng)基的研究和開發(fā)。合肥星肽生物科技有限公司始終致力于為客戶提供可靠的研究材料以及方便快捷的服務(wù)，對購買項(xiàng)目的前期資料提供,中期合同保證,后期貨物跟蹤到*終售后的確保項(xiàng)目準(zhǔn)確到位，都有相關(guān)專業(yè)人士進(jìn)行維護(hù),確保您在合肥合肥星肽生物科技有限公司公司獲得*上等服務(wù)！
|
|
聯(lián)系方式
|
何經(jīng)理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：info@qingbio.com http://www.83pc.cn QQ:514713116
|
1.) Timm DM, Chen J, Sing D, Gage JA, Haisler WL, Neeley SK, Raphael RM, Dehghani M, Rosenblatt KP, Killian TC, Tseng H, Souza GR. (2013) 'A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis.'
2.) Timm DM, Chen J, Sing D, Gage JA, Haisler WL, Neeley SK, Raphael RM, Dehghani M, Rosenblatt KP, Killian TC, Tseng H, Souza GR. (2013) "A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis."?Sci rep. 3.
3.) Cheng SE, Lee IT, Lin CC, Kou YR, Yang CM. (2010) "Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway."?Free Radic Biol Med. 48: 1410-22.
4.) Lee CW, Lee IT, Lin CC, Lee HC, Lin WN, Yang CM. (2010) "Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB."?J Cell Biochem. 109: 1045-56.
5.) Cheng SE, Luo SF, Jou MJ, Lin CC, Kou YR, Lee IT, Hsieh HL, Yang CM. (2009) "Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells."?Free Radic Biol Med. 46: 948-60.
6.) Lin WN, Luo SF, Lin CC, Hsiao LD, Yang CM. (2009) "Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells."?Cell Signal. 21: 1385-95.?
7.) Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. (2009) "Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells."?Toxicol Appl Pharmacol. 237: 8-21.?
8.) Yang CM, Lee IT, Lin CC, Yang YL, Luo SF, Kou YR, Hsiao LD. (2009) "Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells."?Am J Physiol Lung Cell Mol Physiol. 297: L892-902.
9.) Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. (2008) "Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells."?Mol Pharmacol. 73: 1454-64.
10.) Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. (2007) "Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells."?J Cell Physiol. 211: 759-70.
11.) Song Y, Qi H, Wu C. (2007) "Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells."?Respirology. 12: 486-94.
