小膠質(zhì)細(xì)胞是**神經(jīng)系統(tǒng)中的膠質(zhì)細(xì)胞類型之一，是神經(jīng)膠質(zhì)細(xì)胞網(wǎng)絡(luò)的重要組成部分。小膠質(zhì)細(xì)胞出現(xiàn)在大腦由發(fā)育早期向成熟階段轉(zhuǎn)化的過程中，被認(rèn)為是大腦免疫監(jiān)視的主要細(xì)胞。小膠質(zhì)細(xì)胞也表達(dá)?II類主要組織相容性復(fù)合體（MHC?II），向CD4陽性T細(xì)胞呈遞抗原，并能進(jìn)行Fc段介導(dǎo)的胞吞作用，并且與造血細(xì)胞和組織巨噬細(xì)胞分享多種抗原。在大腦發(fā)育或**神經(jīng)系統(tǒng)受傷發(fā)生程序性細(xì)胞死亡后，小膠質(zhì)細(xì)胞能被激活。做為大腦的巨噬細(xì)胞清除組織碎片，受損細(xì)胞或微生物。另外，有大量的證據(jù)表明，小膠質(zhì)細(xì)胞參與多種的生理和病理過程，它們通過與神經(jīng)元和其它膠質(zhì)細(xì)胞共同作用，產(chǎn)生諸如生長因子、細(xì)胞因子等活性物質(zhì)來完成以上功能。
ScienCell實驗室的HM提取自大腦皮層，原代凍存，冰凍運輸。每管細(xì)胞密度超過1×106/ml。細(xì)胞經(jīng)OX-42（CD11b/c）和F4/80免疫熒光鑒定。本細(xì)胞經(jīng)檢測不含HIV-1,?HBV,?HCV,?支原體,?細(xì)菌,?酵母菌和真菌。如采用ScienCell?實驗室特制的培養(yǎng)基，可保證此細(xì)胞生長良好。HM不推薦增值培養(yǎng)。
推薦培養(yǎng)基：小膠質(zhì)細(xì)胞培養(yǎng)基(MM, Cat. #1901)
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貨號
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1900
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產(chǎn)地
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美國
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縮寫
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HM
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規(guī)格
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5 x 10^5 /1ml
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用途
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科研
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儲存
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液氮
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運輸
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干冰
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關(guān)鍵字
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人小膠質(zhì)細(xì)胞 HM 人小膠質(zhì)細(xì)胞 HM 人小膠質(zhì)細(xì)胞 HM 人小膠質(zhì)細(xì)胞 HM 人小膠質(zhì)細(xì)胞 HM 人小膠質(zhì)細(xì)胞 HM
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公司簡介
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合肥星肽生物科技有限公司作為專業(yè)的ScienCell中國代理商，專業(yè)經(jīng)營實驗室科研用原代細(xì)胞、原代細(xì)胞專用培養(yǎng)基、原代細(xì)胞無血清培養(yǎng)基、干細(xì)胞、干細(xì)胞培養(yǎng)基、干細(xì)胞無血清培養(yǎng)基的研究和開發(fā)。合肥星肽生物科技有限公司始終致力于為客戶提供可靠的研究材料以及方便快捷的服務(wù)，對購買項目的前期資料提供,中期合同保證,后期貨物跟蹤到*終售后的確保項目準(zhǔn)確到位，都有相關(guān)專業(yè)人士進(jìn)行維護(hù),確保您在合肥合肥星肽生物科技有限公司公司獲得*上等服務(wù)！
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聯(lián)系方式
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何經(jīng)理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：info@qingbio.com http://www.83pc.cn QQ:514713116
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1.) Yi L, Xiao H, Xu M, Ye X, Hu J, Li F, Li M, Luo C, Yu S, Bian X, Feng H. (2011) "Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma." J Neuroimmunol. 232: 75-82.
2.) Kostianovsky AM, Maier LM, Anderson RC, Bruce JN, Anderson DE. (2008) "Astrocytic regulation of human monocytic/microglial activation." J Immunol. 181: 5425-32.
3.) Wang X, Douglas SD, Song L, Wang YJ, Ho WZ. (2008) "Neurokinin-1 receptor antagonist (aprepitant) suppresses HIV-1 infection of microglia/macrophages." J Neuroimmune Pharmacol. 3: 257-64.
4.) Campbell GR, Watkins JD, Singh KK, Loret EP, Spector SA. (2007) "Human Immunodeficiency Virus Type 1 Subtype C Tat Fails To Induce Intracellular Calcium Flux and Induces Reduced Tumor Necrosis Factor Production from Monocytes." J Virol. 81: 5919-28.
5.) Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB. (2007) "Functional Synergy between CD40 Ligand and HIV-1 Tat Contributes to Inflammation: Implications in HIV Type 1 Dementia." J Immunol. 178: 3226-36.
6.) CAS:siani-Ingoni R, Cabral ES, L nemann JD, Garza Z, Magnus T, Gelderblom H, Munson PJ, Marques A, Martin R. (2006) "Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expression." J Neuropathol Exp Neurol. 65: 540-8.
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1、Question:
Dear whom it may concern, I’m wondering whether your microglia express chemokine receptors particularly, CD36, TLR3, TLR4, TLR7. Any finding by you or your customers are valuable for me to use your cells as the model. Thanks, H.Cho
Answers:
We do not test for the receptors listed. Thank you for your interest in ScienCell products
2、Question:
Hello, Do these human microglia immortalized cells express CD80/86 as normal microglia do when stimulated? Also, are there any publications that utilized this cell line for flow cytometryic analysis? Thanks
Answers:
Human microglia provided by ScienCell are primary cells, not immortalized cell lines. Thank you for your interest
